SIMPLE HERPES
Simple herpes (Herpes simplex, sin. Idle time puzyrkovyj deprive) - the virus disease shown grouped puzyrkovymi by enanthesises and mucosas.
Aetiology and pathogenesis. The originator of simple herpes (VPG) - dermatonejrotropnyj DNA, viruliferous with difficult structure. Breeds in a kernel and a cytoplasma of the infected cells, has 14 hour cycle of reproduction. At acute infectious process in acquisitive cells the virus is intensively reproduced, therefore the amazed cells perish and affiliated virions are liberated.
Distinguish I and II types VPG - originators of not genital and genital forms of disease. The Gerpetichesky infection gets through a skin and mucosas at kisses, intimate affinity with the patient or a virus carrier, at contact to the infected material and air drop way is more often, Through a skin and mucosas the virus takes root into lymphatic system, regionarnye lymph nodes, a blood and an internal, extending in an organism hematogenically and on nervous fibers. Collecting in regionarnyh spinal and cranial cerebral ganglions. VPG is there it is long in a latent condition. After a becoming infected in an organism antibodies to VPG are formed. Their caption is enlarged during 4-5 ned and then remains on all to live at approximately constant level irrespective of, whether the infection has the latent or demonstrative form. The specific antibodies generated in a blood do not warn palindromias, but promote their softer current. At the majority of patients gerpeticheskaja the infection proceeds without the expressed clinical symptoms, quite often accepting the latent form of a carriage of virus. Under the influence of various factors the latent infection is activated and leads to development of clinical relapse. Degree of expression of clinical symptoms depends on a condition of cellular and humoral immunity of an organism of the owner, than and the variety of clinical forms speaks. Under the influence of specific and nonspecific factors of protection series of patients have a restraint of activation of the virus, leading to remission elongation. The incubation interval makes 1 2 days. In immune protection the leading part belongs T to cellular mechanisms of immunity and interferonobrazujushchej to function of leucocytes.
Clinical picture. The primary simple herpes arise after the first contact to a virus. To a bowl it happens at Asthma Information Is characterised by intensity of clinical symptoms. The incubation interval proceeds from several days to 2 ned. Are clinically characterised by group of blisters on the inflamed basis.
Favourite localisation - labiums, a nose. Hardly disease proceeds at newborns as from for a hematogenic dissimination an internal and TSNS can be surprised. At a primary infection one of clinical implications can be acute gerpetichesky a stomatitis. The incubation interval makes 1 8 days, then there is a fever, temperature 39-40пїЅпїЅ, a headache, a malaise, drowsiness. In an oral cavity on an internal surface of labiums, tongue, is more rare on soft and a hard palate, palatal handles and tonsils there are groups of blisters on hydropic giperemirovannom a background. Blisters burst, painful erosions with the rests of an exfoliating epithelium are formed. Regionarnys submandibular lymph nodes are enlarged, painful, on a skin round a mouth there can be absent-minded blisters. At weakened children the virus amazes a liver, a lien and other organs and approximately in 25 % of cases leads to a legal outcome. The relapsing herpes differ smaller intensity and duration of clinical implications. Relapses come from 1 3 times a year to 5 times a month throughout several years, even decades. Sometimes process accepts continuous chronic character: one rashes were not resolved yet, and others appear. Localisation of rashes is usually fixed on a place of introduction of a virus in a skin or a mucosa. Disease relapses are preceded by the prodromal phenomena: the burning sensation, a pricking, an itch, etc. the Characteristic grouped blisters in the size of 1,5-2 mm appear against an erythema, their transparent contents grow turbid, can sometimes become hemorrhagic. The eruption is more often shown by the individual centres consisting of 3-5 grouped blisters, then they are broken off and form painful erosion with festonchatymi contours. Its bottom soft, smooth, reddish, a surface wet. At a secondary becoming infected pustulous flora or a boring erosion turns in superficial jazvochku with the condensed bottom and a small edema on periphery. Arises regionarnyj a lymphadenitis, lymph nodes are moderately painful. Contents of blisters can shrink in buro the yellow thick crusts covering an erosive surface. On a place zaepitelizirovavshihsja erosions remain slowly disappearing krasnovato brownish maculae. Rashes are resolved within 10-14 days. Duration of relapse is enlarged at complication of process by a secondary piogenic infection. Most often the eruption is localised on the person (labiums, a nose, cheeks) and Asthma Information, is more rare on a skin of breeches, in the field of a sacrum, hips, fingers of arms. There are various clinical forms of a current of simple herpes: abortal, hydropic, zosteriformnaja, disseminirovannaja.
The herpetiform eczema of Kaposhi is a serious version of relapsing herpes. Arises at children sick atopicheskim of a dermatitis and an eczema. This acute disease with temperature 39-40пїЅпїЅ, a serious general condition and disseminirovannym a lesion simple herpes of a skin of mainly eczematous sites on which there are groups of the blisters reminding rashes of a chicken pox. The central part of blisters nekrotiziruetsja with formation of hemorrhagic crusts after which tearing away there are cicatrixes. Involving in pathological process of mucosas of an oral cavity, a pharynx, a larynx, a trachea with a lymphadenopathy, a lesion of an internal, TSNS with a lethal outcome is possible.
The genital herpes can be caused TWO types of viruses (Asthma Information). The basic way of a becoming infected of genitals - sexual. Infection occurs at contact to a sick genital herpes or carrier VPG (sexual transfer VPG can occur during the asymptomatic period of disease when genital lesions are absent; an asymptomatic carriage, especially characteristic for VPG 2). The becoming infected of genitals is possible at orogenitalnom contact, at presence at the partner of simple herpes of the person, and also a household way through agents of personal hygiene. From 5 to 30 % of primary episodes of genital herpes causes VPG 1; the relapsing current is more characteristic for an infection caused VPG 2. The risk neonatalnogo becomings infected from mother is high (30-50 %) if it has caught genital herpes nezadolju to sorts, and is low at women who have caught genital VPG in the first polovit pregnancy (about 3 %). The virusemia during pregnancy happens a foetus cause of death, causing to 30 % of spontaneous abortions on early durations of gestation and more than 50 % of late abortions. Clinically genital herpes are shown by relapses spontaneously involjutsionirujushchih in terms from 5 till 7 days of the fine grouped blisters, erosions and jazvochek, accompanied by an itch, a burning sensation and a pain in the field of genitals. mnogoochagovost diseases it is shown by a simultaneous lesion of genitals and urethras, and also anogenitalnoj areas or rectum ampoules. Clinically rashes look as plural fine blisters against the hyperemia centres at which opening the erosions sometimes merging in larger centre with polycyclic edges are formed. Thus at patients the body temperature quite often raises, are enlarged regionarnye lymph nodes, in 30 % of cases there are phenomena gerpeticheskogo an urethritis. Last usually begins suddenly, with poor mucous separated of an urethra in a kind of "a morning drop", is accompanied by an easy pricking and a burning sensation in an urethra at an emiction. The urethritis differs a short current (1-2 ned) and relapses (intervals from several weeks till several years). The chronic prostatitis caused gerpeticheskoj by an infection, clinically does not differ from similar process of other aetiology. At women gerpeticheskie rashes in the form of painful fine blisters and erosions settle down in the field of the big and small sexual labiums, a vulva, a clitoris, a vagina and a uterus neck. At gerpeticheskom tservitsite the uterus neck is hydropic, erozirovana. Acute gerpetichesky the cystitis is accompanied by a fever, urodynias, muddy urine with a blood impurity.
SURROUNDING HERPES Surrounding herpes (herpes zoster, sin. Surrounding deprive) - the virus disease amazing nervous system and a skin.
Aetiology and pathogenesis. The originator of surrounding herpes - virus Varicella zoster - simultaneously is the chicken pox originator. Development surrounding depriving - result of a reactivation of a latent virus after the chicken pox transferred in the childhood. Its reasons - somatopathies, infections, frigorisms, radial influence. Men at the age of 40-70 years during the spring and autumn periods is more often are ill. Clinical picture. The incubation interval is not established. Disease often begins with the prodromal phenomena in the form of a malaise, lifting of temperature, delicacy, a headache, a nausea and a unilateral neuralgia of a certain zone of an innervation. Then and a zone of occurrence of a neuralgia on giperemirovannoj and a hydropic skin there are grouped vesicles, settling down on a course of the amazed nerve and its branches, as a rule, odnostoronne (a bowl along intercostal nerves, on a course of facial, trigeminal nerves). Contents of vesicles soon grow turbid, pustules at which opening the erosions which are becoming covered by crusts are formed are formed. In hard cases arise ulcerative and jazvenno necrotic lesions with dense hemorrhagic crusts. Duration of disease makes from 1 to 3 under. In 2-4 % of cases there can be a generalised form of a lesion with a hyperadenosis and the rashes extended on an integument without severe pains. This form arises at persons with serious accompanying diseases (limfomoj, a leukosis, a cancer of an internal), at patients, is long receiving immunodeiressanty, cytostatics, corticosteroids. The most serious form - gangrenous, developing at weakened and the older persons, suffering a diabetes, a stomach ulcer. Thus formed gangrenous ulcers longly do not heal and leave after itself cicatrixes. The painful syndrome is caused nejrotropnostju a virus, pains can remain long time after the permission of rashes. They stupid, shooting, burning. At a lesion in the field of rash eyes can damage a cornea, a conjunctiva, a sclera, an iris of the eye. The virus can get into a subarachnoid space and cause a meningocephalitis with a serious and long current.
Favourite localisation - labiums, a nose. Hardly disease proceeds at newborns as from for a hematogenic dissimination an internal and TSNS can be surprised. At a primary infection one of clinical implications can be acute gerpetichesky a stomatitis. The incubation interval makes 1 8 days, then there is a fever, temperature 39-40пїЅпїЅ, a headache, a malaise, drowsiness. In an oral cavity on an internal surface of labiums, tongue, is more rare on soft and a hard palate, palatal handles and tonsils there are groups of blisters on hydropic giperemirovannom a background. Blisters burst, painful erosions with the rests of an exfoliating epithelium are formed. Regionarnys submandibular lymph nodes are enlarged, painful, on a skin round a mouth there can be absent-minded blisters. At weakened children the virus amazes a liver, a lien and other organs and approximately in 25 % of cases leads to a legal outcome. The relapsing herpes differ smaller intensity and duration of clinical implications. Relapses come from 1 3 times a year to 5 times a month throughout several years, even decades. Sometimes process accepts continuous chronic character: one rashes were not resolved yet, and others appear. Localisation of rashes is usually fixed on a place of introduction of a virus in a skin or a mucosa. Disease relapses are preceded by the prodromal phenomena: the burning sensation, a pricking, an itch, etc. the Characteristic grouped blisters in the size of 1,5-2 mm appear against an erythema, their transparent contents grow turbid, can sometimes become hemorrhagic. The eruption is more often shown by the individual centres consisting of 3-5 grouped blisters, then they are broken off and form painful erosion with festonchatymi contours. Its bottom soft, smooth, reddish, a surface wet. At a secondary becoming infected pustulous flora or a boring erosion turns in superficial jazvochku with the condensed bottom and a small edema on periphery. Arises regionarnyj a lymphadenitis, lymph nodes are moderately painful. Contents of blisters can shrink in buro the yellow thick crusts covering an erosive surface. On a place zaepitelizirovavshihsja erosions remain slowly disappearing krasnovato brownish maculae. Rashes are resolved within 10-14 days. Duration of relapse is enlarged at complication of process by a secondary piogenic infection. Most often the eruption is localised on the person (labiums, a nose, cheeks) and Asthma Information, is more rare on a skin of breeches, in the field of a sacrum, hips, fingers of arms. There are various clinical forms of a current of simple herpes: abortal, hydropic, zosteriformnaja, disseminirovannaja.
The herpetiform eczema of Kaposhi is a serious version of relapsing herpes. Arises at children sick atopicheskim of a dermatitis and an eczema. This acute disease with temperature 39-40пїЅпїЅ, a serious general condition and disseminirovannym a lesion simple herpes of a skin of mainly eczematous sites on which there are groups of the blisters reminding rashes of a chicken pox. The central part of blisters nekrotiziruetsja with formation of hemorrhagic crusts after which tearing away there are cicatrixes. Involving in pathological process of mucosas of an oral cavity, a pharynx, a larynx, a trachea with a lymphadenopathy, a lesion of an internal, TSNS with a lethal outcome is possible.
The genital herpes can be caused TWO types of viruses (Asthma Information). The basic way of a becoming infected of genitals - sexual. Infection occurs at contact to a sick genital herpes or carrier VPG (sexual transfer VPG can occur during the asymptomatic period of disease when genital lesions are absent; an asymptomatic carriage, especially characteristic for VPG 2). The becoming infected of genitals is possible at orogenitalnom contact, at presence at the partner of simple herpes of the person, and also a household way through agents of personal hygiene. From 5 to 30 % of primary episodes of genital herpes causes VPG 1; the relapsing current is more characteristic for an infection caused VPG 2. The risk neonatalnogo becomings infected from mother is high (30-50 %) if it has caught genital herpes nezadolju to sorts, and is low at women who have caught genital VPG in the first polovit pregnancy (about 3 %). The virusemia during pregnancy happens a foetus cause of death, causing to 30 % of spontaneous abortions on early durations of gestation and more than 50 % of late abortions. Clinically genital herpes are shown by relapses spontaneously involjutsionirujushchih in terms from 5 till 7 days of the fine grouped blisters, erosions and jazvochek, accompanied by an itch, a burning sensation and a pain in the field of genitals. mnogoochagovost diseases it is shown by a simultaneous lesion of genitals and urethras, and also anogenitalnoj areas or rectum ampoules. Clinically rashes look as plural fine blisters against the hyperemia centres at which opening the erosions sometimes merging in larger centre with polycyclic edges are formed. Thus at patients the body temperature quite often raises, are enlarged regionarnye lymph nodes, in 30 % of cases there are phenomena gerpeticheskogo an urethritis. Last usually begins suddenly, with poor mucous separated of an urethra in a kind of "a morning drop", is accompanied by an easy pricking and a burning sensation in an urethra at an emiction. The urethritis differs a short current (1-2 ned) and relapses (intervals from several weeks till several years). The chronic prostatitis caused gerpeticheskoj by an infection, clinically does not differ from similar process of other aetiology. At women gerpeticheskie rashes in the form of painful fine blisters and erosions settle down in the field of the big and small sexual labiums, a vulva, a clitoris, a vagina and a uterus neck. At gerpeticheskom tservitsite the uterus neck is hydropic, erozirovana. Acute gerpetichesky the cystitis is accompanied by a fever, urodynias, muddy urine with a blood impurity.
SURROUNDING HERPES Surrounding herpes (herpes zoster, sin. Surrounding deprive) - the virus disease amazing nervous system and a skin.
Aetiology and pathogenesis. The originator of surrounding herpes - virus Varicella zoster - simultaneously is the chicken pox originator. Development surrounding depriving - result of a reactivation of a latent virus after the chicken pox transferred in the childhood. Its reasons - somatopathies, infections, frigorisms, radial influence. Men at the age of 40-70 years during the spring and autumn periods is more often are ill. Clinical picture. The incubation interval is not established. Disease often begins with the prodromal phenomena in the form of a malaise, lifting of temperature, delicacy, a headache, a nausea and a unilateral neuralgia of a certain zone of an innervation. Then and a zone of occurrence of a neuralgia on giperemirovannoj and a hydropic skin there are grouped vesicles, settling down on a course of the amazed nerve and its branches, as a rule, odnostoronne (a bowl along intercostal nerves, on a course of facial, trigeminal nerves). Contents of vesicles soon grow turbid, pustules at which opening the erosions which are becoming covered by crusts are formed are formed. In hard cases arise ulcerative and jazvenno necrotic lesions with dense hemorrhagic crusts. Duration of disease makes from 1 to 3 under. In 2-4 % of cases there can be a generalised form of a lesion with a hyperadenosis and the rashes extended on an integument without severe pains. This form arises at persons with serious accompanying diseases (limfomoj, a leukosis, a cancer of an internal), at patients, is long receiving immunodeiressanty, cytostatics, corticosteroids. The most serious form - gangrenous, developing at weakened and the older persons, suffering a diabetes, a stomach ulcer. Thus formed gangrenous ulcers longly do not heal and leave after itself cicatrixes. The painful syndrome is caused nejrotropnostju a virus, pains can remain long time after the permission of rashes. They stupid, shooting, burning. At a lesion in the field of rash eyes can damage a cornea, a conjunctiva, a sclera, an iris of the eye. The virus can get into a subarachnoid space and cause a meningocephalitis with a serious and long current.